Flagging Vulnerability & Enforcing GFR Limits
Manual opioid safety assessments are often missed or inconsistent on busy hospital floors. Precision Analgesia automates risk scoring to safeguard patients before scripts are active.
PRODIGY-Aligned Scoring
Calculates Opioid-Induced Respiratory Depression (OIRD) scores based on age, sleep disorders, cardiac, and pulmonary comorbidities.
Organ-Specific Guardrails (Renal Gating)
GFR-gating logic flags active metabolites (e.g. Morphine accumulation). The system automatically enforces a 50% dose reduction warning for compromised renal clearance.
Informed Consent Disclaimers
Every login enforces a clinical responsibility toggle, ensuring the software operates strictly as a decision support aid.
Replacing Static Tables with Pharmacokinetic Modeling
Standard equianalgesic conversion charts fail to model variable half-lives, incomplete cross-tolerance, or slow patch accumulations. Precision Analgesia replaces static formulas with dynamic math.
Dynamic Cross-Tolerance Controls
Allows the clinician to dynamically slide and adjust cross-tolerance reductions (defaulting to safe CDC parameters of 30-50%).
Complex Conversion Matrices
Built-in algorithms for variable half-life Methadone titrations, Fentanyl and Buprenorphine patch conversions, and continuous IV infusions.
CDC-Aligned 2-Phase Tapering
Automatically charts exponential and linear step-downs, plotting a clean step-down graph to prepare safe outpatient discharge tapers.
Standardizing OUD Pathways & Screening
Inpatient admission is a critical window to address substance use. Precision Analgesia provides bedside tools to screen patients and guide transitions to Medication-Assisted Treatment (MAT).
Integrated Screener Batteries
Access validated screeners (DAST-10, ASSIST-Lite, Opioid Risk Tool, PEG Pain & Function Scale) directly at the point of care.
COWS & Induction Protocols
Clinical workflows for buprenorphine inductions based on live Clinical Opiate Withdrawal Scale (COWS) scores.
Multimodal Sparing Options
Recommends evidence-based adjuvants (such as Suzetrigine, Acetaminophen) and non-pharmacological options to spare MME exposure.
Regulatory & Compliance Specifications
Precision Analgesia operates strictly under clear regulatory guardrails to verify it operates as an informational logic layer rather than an active medical device.
Non-Device Clinical Decision Support (CDS)
Precision Analgesia is classified as a Non-Device Clinical Decision Support software tool under Section 3060(o)(1)(E) of the 21st Century Cures Act. The software presents clinical guidelines (CDC 2022, NCCN 2025, and FDA guidelines) transparently, displaying all formulas, equianalgesic ratios, and sources directly in the application's "Algorithm Transparency" and "Citations" interfaces.
It does not directly control, configure, or administer patient dosing hardware (such as infusion pumps), nor does it replace the diagnostic or treatment path decided by the licensed practitioner.
This software is an educational support tool. The clinician retains full, final responsibility for patient care, diagnoses, and prescription quantities. All conversions and calculations should be manually verified against institutional protocols before ordering.
References used in development:
- CDC Clinical Practice Guideline for Prescribing Opioids (2022)
- PRODIGY Clinical Trial (OIRD Respiratory Depression risk factors)
- ASAM National Practice Guideline for OUD treatment (2020)
- NCCN Guidelines for Adult Cancer Pain Management (2025)